CD8⁺CD28⁺PD1^- T Cells as a Prognostic Biomarker in Endometrial Cancer.

ABSTRACT: Endometrial cancer (EC) is an immunogenic tumor, with CD8⁺ T cells playing a pivotal role in antitumor immunity. Overexpression of PD1 suppresses T cell function by inhibiting CD28, a critical co-stimulatory molecule. Classifying CD8⁺ T cells based on PD1 and CD28 expression provides valuable insights into the immune microenvironment of EC. Peripheral blood samples from 120 EC patients and tumor tissue samples from 81 EC patients were analyzed via flow cytometry. CD8⁺ T cells were categorized according to PD1 and CD28 expression, and their associations with clinical characteristics were systematically evaluated. Peripheral CD28^-/CD8⁺ and PD1⁺/CD8⁺ T cell proportions were significantly associated with several high-

SUBMITTER: Nie Y 

PROVIDER: S-EPMC11940843 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature