Association Between In-Utero Exposure to Antibiotics and Offspring's Hearing Loss: A Systematic Review and Meta-Analysis.

ABSTRACT: Objectives: Antibiotic exposure during pregnancy is common, accounting for over 80% of all medications prescribed. Antibiotics in pregnancy are linked to increased childhood disease risk, through direct toxicity or potentially microbiome dysbiosis. This systematic review investigated the relationship between in-utero exposure to antibiotics and childhood hearing loss. Methods: We searched Ovid Medline, Embase, and PubMed for studies examining antibiotic exposure during pregnancy and its associations with hearing loss in offspring. Studies with children whose mothers had data on antibiotic exposure during pregnancy were selected. The meta-analysis calculated (1) pooled prevalence of childhood hearing loss and (2) pooled odds ratios (ORs) for associations between in-utero expos

SUBMITTER: Wang J 

PROVIDER: S-EPMC11940907 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature