Dysregulation of T Follicular Helper and Regulatory Cells in <i>IRF5</i>-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients.

ABSTRACT: T follicular helper (Tfh) and T follicular regulatory cells (Tfr) are required for antibody production and are dysregulated in SLE. Genetic variants within or near interferon regulatory factor 5 (IRF5) are associated with SLE risk. We previously reported higher plasma cells and autoantibodies in healthy IRF5-SLE homozygous risk carriers. Here, we report the dysregulation of circulating Tfh and Tfr in both SLE patients and presymptomatic IRF5-SLE homozygous risk carriers.

SUBMITTER: Matta B 

PROVIDER: S-EPMC11941281 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature