Setting the Stage for Branched-Chain Amino Acids Use in Neurological Pathologies: Does a Single Oral Dose Provide Hours of Elevated Systemic Levels?

ABSTRACT:

Background

Recent studies have demonstrated that branched-chain amino acids are neuroprotective and neurorestorative. Branched-chain amino acid supplements are now being recommended to be taken before contact sports to reduce concussions. While peaks and troughs in branched-chain amino acids have previously been reported in hospital settings, the metabolism of a single recommended dose of over-the-counter branched-chain amino acids has yet to be elucidated.

Methods

We analyzed a patented branched-chain amino acid product to assess its metabolism in 10 healthy adults.

Results

Over the defined time points, measured levels of branched-chain amino acids remained significantly elevated when compared to the physiological baseline. The elevations in measured plasma levels in

SUBMITTER: Mathew E 

PROVIDER: S-EPMC11941354 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature