First demonstration of implication of hereditary alpha-tryptasaemia in vasospastic angina: a case report.

ABSTRACT:

Background

Vasospastic angina is a common condition. In cases of poor therapeutic response, less common causes should be explored.

Case summary

A 50-year-old woman with vasospastic angina was diagnosed with significant fluctuation in response to treatment without explanation that led to the suspicion of an allergic phenomenon. A diagnosis of hereditary alpha-tryptasaemia was made, and introduction of a second-generation H1-antihistamine has enabled effective control of previously treatment-resistant vasospastic coronary disease.

Discussion

The case shows the first time the involvement of hereditary alpha-tryptasaemia in vasospastic angina. Future pathophysiological investigations will be needed to further explore the connection between these two pathologies.

SUBMITTER: Caullery B 

PROVIDER: S-EPMC11941469 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature