Genomic Landscape of Breast Cancer: Study Across Diverse Ethnic Groups.

ABSTRACT: Background: Breast cancer (BC) is the most common cancer among women worldwide, with incidence and mortality rates varying across ethnic groups due to sociodemographic, clinicopathological, and genomic differences. This study aimed to characterize the genomic landscape of BC in diverse ethnic groups using computational tools to explore these variations. Methodology: cBioPortal was used to analyze genomic, clinicopathological, and sociodemographic data from 1084 BC samples. Mutated genes were classified based on GeneCards platform data. Enrichment analysis was performed with CancerHallmarks, and genes not found were compared with MSigDB's Hallmark Gene Sets. Genes absent from both were further analyzed using NDEx through Cytoscape.org to explore their role in cancer. Result

SUBMITTER: Garibaldi-Rios AF 

PROVIDER: S-EPMC11941751 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature