Reactive Oxygen Species (ROS) in Metabolic Disease-Don't Shoot the Metabolic Messenger.

ABSTRACT: Reactive oxygen species (ROS) are widely considered key to pathogenesis in chronic metabolic disease. Consequently, much attention is rightly focused on minimising oxidative damage. However, for ROS production to be most effectively modulated, it is crucial to first appreciate that ROS do not solely function as pathological mediators. There are >90 gene products specifically evolved to generate, handle, and tightly buffer the cellular concentration of ROS. Therefore, it is likely that ROS plays a role as integral homeostatic signalling components and only become toxic in extremis. This review explores these commonly overlooked normal physiological functions, including how ROS are generated in response to environmental or hormonal stimuli, the mechanisms by which the signals are propagated

SUBMITTER: Lindsay RT 

PROVIDER: S-EPMC11942130 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature