Glycosylation Regulation by TMEM230 in Aging and Autoimmunity.

ABSTRACT: Aging is often a choice between developing cancer or autoimmune disorders, often due in part to loss of self-tolerance or loss of immunological recognition of rogue-acting tumor cells. Self-tolerance and cell recognition by the immune system are processes very much dependent on the specific signatures of glycans and glycosylated factors present on the cell plasma membrane or in the stromal components of tissue. Glycosylated factors are generated in nearly innumerable variations in nature, allowing for the immensely diverse role of these factors in aging and flexibility necessary for cellular interactions in tissue functionality. In previous studies, we showed that differential expression of TMEM230, an endoplasmic reticulum (ER) protein was associated with specific signatures of enzymes re

SUBMITTER: Piscitelli E 

PROVIDER: S-EPMC11942208 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature