Analysis of the Expression Patterns of piRNAs in Response to Microsporidian Invasion in Midgut of Workers (<i>Apis cerana cerana</i>).

ABSTRACT: Piwi-interacting RNAs (piRNAs) play an essential part in transposon suppression, DNA methylation, and antiviral responses. The current understanding of the roles of piRNAs in honeybees is very limited. This study aims to analyze the expression pattern and regulatory role of piRNAs in the Asian honeybee (Apis cerana) responding to infection by Nosema ceranae, based on previously gained small RNA-seq data. Here, 450 and 422 piRNAs were respectively identified in the midgut tissues of Apis cerana cerana workers at 7 and 10 days post-inoculation (dpi) with N. ceranae, including 539 non-redundant ones. Additionally, one up-regulated (piR-ace-1216942) and one down-regulated (piR-ace-776728) piRNA were detected in the workers' midgut at 7 dpi, targeting 381 mRNAs invol

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11942432 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature