Porcine Bone Extracellular Matrix Hydrogel as a Promising Graft for Bone Regeneration.

ABSTRACT: Bone defects resulting from trauma, tumors, or congenital conditions pose significant challenges for natural healing and often require grafting solutions. While autografts remain the gold standard, their limitations, such as restricted availability and donor site complications, underscore the need for alternative approaches. The present research investigates the potential of porcine-derived bone extracellular matrix (pbECM) hydrogel as a highly promising bioactive scaffold for bone regeneration, comparing it to the human-derived bECM (hbECM). Porcine and human cancellous bones were decellularized and characterized in terms of their composition and structure. Further, the ECMs were processed into hydrogels, and their rheological properties and cytocompatibility were studied in vitro while t

SUBMITTER: Hayam R 

PROVIDER: S-EPMC11942433 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature