LXG Toxins of Bacillus Velezensis Mediate Contact-Dependent Inhibition in a T7SS-Dependent Manner to Enhance Rhizosphere Adaptability.

ABSTRACT: Rhizosphere bacteria always compete intensely for ecological niches, employing various strategies to inhibit the growth of microbial competitors. One such strategy, contact-dependent inhibition (CDI), involves the direct delivery of toxic proteins into competing neighboring bacteria by a secretion system, leading to the inhibition of their growth. However, the ecological function of CDI competition in the natural environment remains unclear. In this study, we examined the role of the type VII secretion system (T7SS) substrate LXG domain-containing protein in the rhizobacterium Bacillus velezensis SQR9 and found that SQR9 encodes LXG toxins mediate contact-dependent inhibition against other Bacillus strains in biofilms. Transcriptional analysis revealed that the expression of

SUBMITTER: Shu X 

PROVIDER: S-EPMC11942605 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature