Spatial Platform for Periodontal Ligament Angulation and Regeneration: In Vivo Pilot Study.

ABSTRACT: The periodontal ligament (PDL) is a fibrous connective tissue that anchors the tooth-root surface to the alveolar bone with specific orientations. It plays a crucial role in functional restoration, optimal position stabilities, biomechanical stress transmission, and appropriate tissue remodeling in response to masticatory loading conditions. This pilot study explored spatial microarchitectures to promote PDL orientations while limiting mineralized tissue formation. A computer-designed perio-complex scaffold was developed with two parts: (1) PDL-guiding architectures with defined surface topography and (2) a bone region with open structures. After SEM analysis of micropatterned topographies on PDL-guiding architectures, perio-complex scaffolds were transplanted into two-wall periodontal def

SUBMITTER: Kim MG 

PROVIDER: S-EPMC11942940 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature