The Role of Enoyl Reductase in the Monacolin K Biosynthesis Pathway in <i>Monascus</i> spp.

ABSTRACT: Monacolin K (MK), a secondary metabolite produced by Monascus spp. with the ability to inhibit cholesterol production, is structurally identical to lovastatin produced by Aspergillus terreus. In the lovastatin biosynthetic pathway, the polyketide synthase (PKS) encoded by lovB must work together with the enoyl reductase encoded by lovC to ensure lovastatin production. However, it is unclear whether mokA and mokE in the MK gene cluster of Monascus spp., both of which are highly homologous to lovB and lovC, respectively, also have the same functions for MK biosynthesis. In the current study, the high-yielding MK M. pilosus MS-1 was used as the research object, and it was found that the enoyl reductase domain of MokA may be

SUBMITTER: Yao T 

PROVIDER: S-EPMC11943018 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature