The Effect on Extubation of Early vs. Late Definitive Closure of the Patent Ductus Arteriosus in Premature Infants: A Target Trial Emulation Using Electronic Health Records.

ABSTRACT: Background/Objectives: Premature infants are often referred for the definitive procedural closure of the patent ductus arteriosus (PDA) with the failure of, or contraindication to, pharmacotherapy and the inability to wean respiratory support. However, once this need is identified, the importance of expedited closure is unclear. The objective of this study was to compare the effect of the timing of definitive closure (i.e., surgical ligation or device occlusion) on early respiratory outcomes in premature infants. Method: We first specify a hypothetical randomized trial (the "target trial") that would estimate the effect on extubation of early (0-4 days from referral) vs. late (5-14 days from referral) definitive PDA closure. We then emulate this target trial using a single-in

SUBMITTER: Du Z 

PROVIDER: S-EPMC11943036 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature