Association of Endothelial Nitric Oxide Synthase Polymorphisms with Clinical Severity in Patients with COVID-19.

ABSTRACT: Background/Objectives: To elucidate the factors that contribute to individual variability in the progression of COVID-19, experiments on endothelial nitric oxide synthase polymorphisms have been reported. Nitric oxide synthase (NOS3) is located in the endothelium and is involved in the regulation of inflammation and vascular homeostasis. In this study, we investigated the association between COVID-19 severity and NOS3 G894T and NOS3 27-bp VNTR 4b/a genetic polymorphisms. Methods: Patients with COVID-19 (n = 178) were divided into Group 1 (mild disease) and Group 2 (severe disease) based on oxygen saturation levels in room air (Group 1, SpO₂ ≥ 93%, n = 107; and Group 2, SpO₂ < 93%, n = 73) and hospitalization requirements. Genotyping was per

SUBMITTER: Idikut A 

PROVIDER: S-EPMC11943162 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature