Markers of Hemophagocytic Lymphohistiocytosis Are Associated with Mortality in Critically Ill Patients.

ABSTRACT: Background: Critically ill patients often display systemic immune dysregulation and increased inflammatory activity. Hemophagocytic lymphohistiocytosis (HLH) represents a rare syndrome defined by the inappropriate survival of cytotoxic T cells and the occurrence of cytokine storms. Although HLH is characterized by relatively high mortality rates, little is known about the predictive value of its diagnostic criteria. Accordingly, our objective was to evaluate these properties within an unselected cohort of critically ill patients admitted to a tertiary intensive care unit (ICU). Methods: This single-center prospective observational study included 176 consecutive patients. Available HLH criteria at admission were assessed, including sCD25 measurements performed using ELISA.

SUBMITTER: Lenz M 

PROVIDER: S-EPMC11943210 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature