Oral Anticoagulation Choice and Dosage in Very Elderly Patients with Atrial Fibrillation.

ABSTRACT:

Background

Selecting the optimal oral anticoagulation (OAC) therapy for elderly patients with atrial fibrillation (AF) remains challenging. Our real-world study investigates clinical factors guiding OAC prescription patterns and compares outcomes between full- and reduced-dose direct-acting oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) in this demographic.

Methods

This post hoc analysis of the MISOAC-AF trial focused on hospitalized AF patients aged ≥ 75 years prescribed OAC at discharge. Predictors of VKA and reduced DOAC dosing were identified using adjusted odds ratios (aORs). Cox regression models calculated adjusted hazard ratios (aHRs) for primary (all-cause mortality) and secondary outcomes (stroke, bleeding, AF or heart failure hospitalization, cardiov

SUBMITTER: Zergioti M 

PROVIDER: S-EPMC11943373 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature