Relationship Between 8-iso-prostaglandin-F_2α and Predicted 10-Year Cardiovascular Risk in Hypertensive Patients.

ABSTRACT:

Background

8-iso-prostaglandin-F_2α (8-iso-PGF_2α) is a recognized marker of oxidative stress. Previous studies suggested that 8-iso-PGF_2α plays an important role in the pathogenesis of hypertension and cardiovascular (CV) diseases. However, limited data exist on the prognostic role of 8-iso-PGF_2α in hypertensive patients undergoing primary prevention. The aim of this study was to assess the relationship between 8-iso-PGF_2α and 10-year CV risk, as predicted by validated equations in hypertension patients without CV diseases.

Materials and methods

A total of 432 individuals aged 40-75 years were enrolled. Plasma 8-iso-PGF_2α was assessed through the ELISA method. CV risk was calculated by using the Framingham Risk

SUBMITTER: Geraci G 

PROVIDER: S-EPMC11943662 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature