Anti-Neuroinflammatory Eremophilane Sesquiterpenoids from Marine-Derived Fungus <i>Phoma</i> sp. DXH009.

ABSTRACT: Three new eremophilane sesquiterpenoids (1-3), together with six known analogues, were isolated from the marine-derived fungus Phoma sp. DXH009. Their structures were elucidated through detailed NMR and MS spectroscopic analysis, and the absolute configurations of 1-4 were determined by conformational analysis and quantum chemical TDDFT-ECD calculation. Their anti-neuroinflammatory activities were evaluated using the lipopolysaccharide (LPS)-induced BV2 microglial cells. The results indicated that compound 5 (dihydrosporogen AO-1) exhibited significant inhibitory effects on the production of nitric oxide (NO) levels (EC₅₀ = 3.11 μM) with less cytotoxicity, leading to a reversal effect in inducing microphage polarization in LPS-treated BV

SUBMITTER: Yang G 

PROVIDER: S-EPMC11943946 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature