The Benthic Dinoflagellate <i>Coolia malayensis</i> (Dinophyceae) Produces an Array of Compounds with Antineoplastic Activity in Cells of Tumor Origin.

ABSTRACT: Among aquatic organisms, marine dinoflagellates are essential sources of bioactive metabolites. The benthic dinoflagellate Coolia malayensis produces metabolites that have exhibited substantial and specific cytotoxicity on cancer cells; however, isolation and identification of the purified compounds remain a challenge. This study reports C. malayensis biomass multi-step extraction plus chemical analyses for identifying compounds with antineoplastic activity. Through bio-directed fractionation, the cytotoxicity of extracts and fractions was tested on H1299 (lung), PC-3 (prostate), HeLa (cervical), and MCF-7 (breast) cancer cell lines. Dichloromethane (DCM) phase, hydroalcoholic (HYD) secondary extract, and methanolic (MET) extract showed cytotoxic effects on all cell lines. Ac

SUBMITTER: Morales-Montesinos IB 

PROVIDER: S-EPMC11944075 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature