The Lipid Composition of the Exo-Metabolome from <i>Haemonchus contortus</i>.

ABSTRACT: Background/Objectives: Metabolomic studies of different parasite-derived biomolecules, such as lipids, are needed to broaden the discovery of novel targets and overcome anthelmintic resistance. Lipids are involved in diverse functions in biological systems, including parasitic helminths, but little is known about their role in the biology of these organisms and their impact on host-parasite interactions. This study aimed to characterize the lipid profile secreted by Haemonchus contortus, the major parasitic nematodes of farm ruminants. Methods: H. contortus adult worms were recovered from infected sheep and cultured ex vivo. Parasite medium was collected at different time points and samples were subjected to an untargeted global lipidomic analysis. Lipids were e

SUBMITTER: Godoy P 

PROVIDER: S-EPMC11944095 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature