Predicting the Rate Structure of an Evolved Metabolic Network.

ABSTRACT: Background: When glucose molecules are metabolized by a biological cell, the molecules are constrained to flow along distinct reaction trajectories, which are defined by the cell's underlying metabolic network. Methods: Using the computational technique of Elementary Mode Analysis, the entire set of all possible trajectories can be enumerated, effectively allowing metabolism to be viewed in a discretized space. Results: With the resulting set of Elementary Flux Modes (EMs), macroscopic fluxes, (of both mass and energy) that cross the cell envelope can be computed by a simple, linear combination of the individual EM trajectories. The challenge in this approach is that the usage probability of each EM is unknown. But, because the analytical framework we have adopted allo

SUBMITTER: Srienc F 

PROVIDER: S-EPMC11944149 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature