Genome Mining-Guided Discovery of Two New Depsides from <i>Talaromyces</i> sp. HDN1820200.

ABSTRACT: Depsides and their derivatives are a class of polyketides predominantly found in fungal extracts. Herein, a silent nonreducing polyketide synthase (TalsA)-containing gene cluster, which was identified from the Antarctic sponge-derived fungus Talaromyces sp. HDN1820200, was successfully activated through heterologous expression in Aspergillus nidulans. This activation led to the production of two novel depsides, talaronic acid A (1) and B (2), alongside three known compounds (3-5). The further co-expression of TalsA with the decarboxylase (TalsF) demonstrated that it could convert 2 into its decarboxylated derivative 1. The structural elucidation of these compounds was achieved using comprehensive 1D and 2D-NMR spectroscopy, which was

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11944171 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature