Dengue Virus Inhibitors as Potential Broad-Spectrum Flavivirus Inhibitors.

ABSTRACT: Background. Flaviviruses spread from endemic to non-endemic areas, causing illness in millions of people worldwide. The lack of effective therapies and the rapid expansion of flaviviral infections worldwide emphasize the importance of finding effective antivirals to treat such diseases. Objectives. To find out the potential broad-spectrum flavivirus inhibitors among previously reported inhibitors of DENV2/DENV4. Methods. The cytotoxicity of compounds was tested using WST-1 assay. The compounds were tested for their ability to inhibit the infection of DENV2, ZIKV, KUNV, and TBEV, and the most active compounds were also analyzed using the replicon-based assay. Interactions of one of the identified inhibitors with possible viral targets were studied using molecular dynami

SUBMITTER: Ivanova L 

PROVIDER: S-EPMC11944514 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature