Carbamoylated Erythropoietin Rescues Autism-Relevant Social Deficits in BALB/cJ Mice.

ABSTRACT: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects over 2% of the population worldwide and is characterized by repetitive behaviors, restricted areas of interest, deficits in social communication, and high levels of anxiety. Currently, there are no known effective treatments for the core features of ASD. The previous literature has established erythropoietin (EPO) as a promising antidepressant, working as a potent neurogenic and neurotrophic agent with hematopoietic side effects. Carbamoylated erythropoietin (CEPO), a chemically engineered non-hematopoietic derivative of EPO, appears to retain the neuroprotective factors of EPO without the hematologic properties. Recent evidence shows that CEPO corrects stress-related depressive behaviors in BALB/cJ (BALB) mice, w

SUBMITTER: Street AL 

PROVIDER: S-EPMC11944669 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature