Bioactive Secondary Metabolites of Two Chinese Edible Boletes, <i>Phlebopus portentosus</i> and <i>Butyriboletus roseoflavus</i>.

ABSTRACT: This study investigated the phytochemical profiles and bioactivities of two edible boletes from Southwestern China, Phlebopus portentosus and Butyriboletus roseoflavus. A total of 33 secondary metabolites, comprising 15 alkaloids, 4 pulvinic acid derivative pigments, and 14 ergosterols, were isolated and identified. To our best knowledge, boletesine A (1), boletesine B (2), and cis-xerocomic acid (16) were previously undescribed compounds. The new structures were established by extensive spectroscopic methods and chemical calculations. Compound 1 features a hitherto unknown hybrid skeleton formed between a 2-formylpyrrole-alkaloid and a dopacetic acid (DOPAC) via a Michael addition reaction. Bioactivity assays revealed the neuroprotective ef

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11944884 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature