Flexible Formation of Nanoparticles: Selectively Self-Assembling with Glycoclusters to Form Nano-Photosensitizers for Multipurpose Bioimaging and Photodynamic Therapy.

ABSTRACT: The smart construction of nano-photosensitizers (PSs) is significant for multipurpose applications, such as bioimaging, efficient photodynamic anti-tumor or anti-bacterial studies. This work reports a flexible self-assembling strategy for the construction of nano-PSs, in which PSs spontaneously form amorphous aggregates for killing bacteria, or self-assemble with tetraphenylethene (TPE) based glycoclusters (TPE-Glc₄) to construct glyco-dots for cell imaging and photodynamic anti-tumor studies. Tricyanofuran (TCF) and TPE units were bridged with furan or thiophene moiety to construct two PSs (1 and 2) with NIR fluorescence in monomers, and a performance of the aggregation-induced generation of reactive oxygen species (AIG-ROS) in an aggregated state. Compared

SUBMITTER: He KL 

PROVIDER: S-EPMC11944942 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature