Immunomodulatory Effects of a Standardized Botanical Mixture Comprising <i>Angelica gigas</i> Roots and <i>Pueraria lobata</i> Flowers Through the TLR2/6 Pathway in RAW 264.7 Macrophages and Cyclophosphamide-Induced Immunosuppression Mice.

ABSTRACT: Background: As the population ages, enhancing immune function is crucial to mitigating age-related physiological decline. Since immunostimulant drugs are known to have potential side effects, medicinal plants emerge as promising candidates offering a safer alternative. To leverage the advantages of medicinal plants with fewer side effects and develop a potent immune-enhancing agent, we investigated the efficacy of a novel immunomodulatory candidate derived from the combination of Angelica gigas and Pueraria lobata (CHL). Methods: In vitro, CHL was treated in RAW 264.7 macrophages at various time points, and the experiments conducted in the study were performed using ELISA, Western blot, and RT-qPCR analysis. In vivo, C57BL/6 mice were administrated CHL for 16 da

SUBMITTER: Jang SY 

PROVIDER: S-EPMC11944983 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature