The Effect of Fatty Acid Desaturase on Cardiovascular Lipid Biomarkers Depends on Circulating ω-3 and ω-6 Polyunsaturated Fatty Acids in the UK Biobank.

ABSTRACT:

Objectives

The objective of this study is to outline a framework for how fatty acids may be acting as mediators/suppressors and/or moderators of an individual's genetic predisposition for cardiovascular lipid biomarkers.

Methods

All UK Biobank participants with demographic and lifestyle variables, circulating cardiovascular lipids, and NMR-measured fatty acid data collected at the baseline visit (N = 229,859) were included in analyses. We fit four separate linear regression models, one for each of the following common measures of cardiovascular lipids: total cholesterol, HDL-c, LDL-c, and total triglycerides. Each model predicted cardiovascular lipids by an individual's FADS (a well-known fatty acid desaturase gene complex) haplotype, with the addition of indiv

SUBMITTER: Arrington CE 

PROVIDER: S-EPMC11945029 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature