Genomic Diversity, Virulome, and Resistome of <i>Streptococcus agalactiae</i> in Northeastern Brazil: Are Multi-Host Adapted Strains Rising?

ABSTRACT: Streptococcus agalactiae, known as group B streptococci (GBS), colonizes the digestive and genitourinary tracts and causes neonatal diseases and infections in immunocompromised and elderly individuals. GBS neonatal disease prevention includes intrapartum antibiotic prophylaxis. We characterized 101 GBS isolates obtained from patients in João Pessoa, northeastern Brazil, owing to the need to develop and implement vaccines to prevent GBS infections. Capsular types were determined using multiplex-PCR, and antibiotic susceptibility profiles were determined using disc diffusion or the gradient strip method. Clonal diversity was evaluated using pulsed-field gel electrophoresis. Fourteen selected isolates had the genome sequenced and evaluated for virulence and resistance genes. The GBS po

SUBMITTER: Perez VP 

PROVIDER: S-EPMC11945199 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature