Multivalent Exosome Based Protein Vaccine: A "Mix and Match" Approach to Epidemic Viruses' Challenges.

ABSTRACT: Background: Endemic viruses are becoming increasingly the norm, and the development of a rapid and effective vaccine is necessary. Methods: Here, we used our StealthX^TM exosome platform to express either Influenza H3 (StealthX^TM-Hemagglutinin, STX-H3), SARS-CoV-2 Delta spike (StealthX^TM-Spike, STX-S) or respiratory syncytial virus proteins (StealthX^TM-RSV fusion protein, STX-RSV) protein on the membrane surface and facilitate their trafficking to the exosomes. Results: The administration of exosomes carrying one of the antigens by themselves resulted in a strong immune response with the production of a potent humoral and cellular immune response in mice. Interestingly, these effects were obtained with the administration of na

SUBMITTER: Cacciottolo M 

PROVIDER: S-EPMC11945559 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature