Inflammatory Responses to Non-Typeable <i>Haemophilus influenzae</i> Clinical Isolates from Invasive and Non-Invasive Infections.

ABSTRACT: Non-typeable Haemophilus influenzae (NTHi) is often asymptomatically carried in the upper airways but can cause a wide spectrum of disease conditions, from local respiratory tract infections to invasive disease such as sepsis or meningitis. The factors driving NTHi's transition from benign carriage to severe systemic disease remain poorly understood. It is unknown whether NTHi strains associated with invasive or non-invasive disease differ in their capacity to trigger inflammatory responses in innate immune cells. To address this question, we have used an in vitro infection model of human THP-1 cells differentiated to macrophages. To evaluate inflammatory responses, we studied the expression of 3 prototypic pro-inflammatory molecules, ICAM-1, TNF-α, and IL-1β. The role of lipooligos

SUBMITTER: Huska B 

PROVIDER: S-EPMC11945879 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature