Exploring the Anti-Chagas Activity of <i>Zanthoxylum chiloperone</i>'s Seedlings Through Metabolomics and Protein-Ligand Docking.

ABSTRACT: This publication reports the controlled cultivation of Zanthoxylum chiloperone var. angustifolium Engl. (Rutaceae) in several growth substrates under controlled greenhouse conditions. This plant is well-known for its anti-Chagas (trypanocidal) activity, related to the presence of several β-carboline alkaloids. The metabolomic study of Z. chiloperone seedlings over two years of growth (2018-2020) was performed using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS). The canthin-6-one alkaloids, canthin-6-one and 5-methoxy-canthin-6-one, were putatively identified in Z. chiloperone extracts. Finally, in vitro and in silico studies of trypanocidal activity were performed, suggesting that canthin-6-one alkaloids could

SUBMITTER: de Bilbao NV 

PROVIDER: S-EPMC11946004 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature