Pre-diagnostic 25-hydroxyvitamin D levels and subsite-specific colorectal cancer risk: a nested case-control study from the Norwegian Women and Cancer Study (NOWAC).

ABSTRACT: Colorectal cancer (CRC), the third most common cancer globally, causes over 900 000 deaths annually. Although vitamin D is observed to have potential anti-carcinogenic properties, research findings on its preventable effect against CRC remain inconclusive. Notably, different subsites within the colon and rectum may be associated with distinct risk factors. While some studies have explored this relationship with circulating 25-hydroxyvitamin D (25(OH)D), the results remain contradictory. Our study employed a nested case-control design, involving 775 CRC cases matched with 775 cancer-free controls based on age, region of living and the time of blood sampling. The study was conducted within the Norwegian Women and Cancer post-genome cohort, which comprises approximately 50 000 women. We measu

SUBMITTER: Paulsen EM 

PROVIDER: S-EPMC11946035 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature