Early Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induces Necroptosis in Immune Cells of Peripheral Lymphoid Organs.

ABSTRACT: The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) has caused huge economic losses to the pig industry in China. This study evaluated the damage to peripheral immune tissues in the early infection of HP-PRRSV, including the hilar lymph nodes, mandibulares lymph nodes, inguinales superficials lymph nodes, spleens, and tonsils. HP-PRRSV infection led to a reduction in CD4⁺ and CD8⁺ T cells, as well as CD19⁺ B cells, in the tonsils. Additionally, CD163⁺ macrophages and CD56⁺ NK cells increased in all peripheral lymphoid organs, with NK cells migrating toward the lymphoid follicles. However, no significant changes were observed in CD11c⁺ dendritic cells. RNA-seq analysis showed the down-regulati

SUBMITTER: Xu J 

PROVIDER: S-EPMC11946179 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature