The Role of cf-HPV DNA as an Innovative Biomarker for Predicting the Recurrence or Persistence of Cervical Cancer.

ABSTRACT:

Background

Cervical cancer is highly prevalent among women in Amazonas, Brazil, mainly due to low screening coverage, and is diagnosed at a late stage, which compromises the treatment efficacy and survival rates. After treatment, recurrence is frequent, and there are few follow-up options to detect it. This highlights the urgent need for less-invasive biomarkers to monitor affected patients.

Methods

This study employed real-time PCR, targeting the E7 gene of HPV types 16 and 18 to analyze cell-free DNA from plasma samples from 39 cervical cancer patients treated at the Oncology Control Center Foundation in Amazonas, Brazil.

Results

cf-HPV 16 DNA was detected in 54% of the samples before treatment. The socioeconomic and behavioral data showed that 46.2% of the patients

SUBMITTER: Poinho M 

PROVIDER: S-EPMC11946245 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature