Emergence of Tigecycline-Nonsusceptible Carbapenem-Resistant <i>Klebsiella pneumoniae</i> with Metallo-β-Lactamase and Transferable Ceftazidime-Avibactam Resistance in China.

ABSTRACT: In recent years, resistance of Klebsiella pneumoniae to the clinical last-resort drugs carbapenem and tigecycline has intensified, including Metallo-β-Lactamase-producing K. pneumoniae (MBL-KP), which demonstrated resistance to ceftazidime-avibactam (CZA), posing a significant public health threat. This study focused on the carbapenems, CZA, and tigecycline resistance mechanisms of MBL-producing Carbapenem-resistant K. pneumoniae (MBL-CRKP). A retrospective study and genomic epidemiological analysis of Carbapenem-resistant K. pneumoniae (CRKP) strains isolated from Yangzhou City, Jiangsu Province, China, between 2016 and 2023 was conducted. The detection rate of CRKP in Yangzhou City has increased significantly in recent years, with five strains carrying the Met

SUBMITTER: Ni Y 

PROVIDER: S-EPMC11946248 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature