Decreased citalopram concentration caused by enzyme induction effect of rifampin: a case report.

ABSTRACT: Citalopram is a selective serotonin reuptake inhibitor used to treat depression and various anxiety disorders, which is mainly metabolized by the P450 (CYP) enzyme. Rifampin is a rifamycin with bactericidal activity against Mycobacterium tuberculosis. Rifampin significantly induces the P450 (CYP) enzyme system, which makes it susceptible to potential drug interactions with other medications. However, there have been few reports on the possible interaction between rifampin and citalopram. We report a 76-year-old patient who had been taking citalopram 20 mg daily for long-term treatment of depression. After 2 months of rifampin treatment for tuberculosis, the patient presented with intractable depressive symptoms, insomnia, and a profound sense of hopelessness. The trough plasma conce

SUBMITTER: Liu J 

PROVIDER: S-EPMC11946286 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature