Whole exome sequencing as a screening tool in dogs: A pilot study.

ABSTRACT:

Background

Whole-exome sequencing (WES) is used to selectively sequence all exons of protein-coding genes. WES is considered as a cost-effective and direct approach for identifying phenotype-associated variants in protein-coding regions and is as such situated between the traditional Sanger sequencing and whole genome sequencing (WGS). While WES is already widely used as a clinical tool in human and medical genetics, its use in veterinary medicine is currently restricted to research purposes. In this article, we aimed to provide baseline performance characteristics of a WES design to assess its suitability with future applications in veterinary clinical genetics in mind.

Methods

To assess the potential of WES in a clinical setting for dogs, 49 canine samples underwent captur

SUBMITTER: Boeykens F 

PROVIDER: S-EPMC11946360 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature