Investigating plasticity within the interleukin-6 family with AlphaFold-Multimer.

ABSTRACT: Cytokines are important soluble mediators that are involved in physiological and pathophysiological processes. Among them, members of the interleukin-6 (IL-6) family of cytokines have gained remarkable attention, because especially the name-giving cytokine IL-6 has been shown to be an excellent target to treat inflammatory and autoimmune diseases. The IL-6 family consists of nine members, which activate their target cells via combinations of non-signaling α- and/or signal-transducing β-receptors. While some receptor combinations are exclusively used by a single cytokine, other cytokine receptor combinations are used by multiple cytokines. Research in recent years unraveled another level of complexity: several cytokine cannot only signal via their canonical receptors, but can bind to and si

SUBMITTER: Dusterhoft S 

PROVIDER: S-EPMC11946507 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature