In Vitro Enzymatic and Computational Assessments of Pyrazole-Isatin and Pyrazole-Indole Conjugates as Anti-Diabetic, Anti-Arthritic, and Anti-Inflammatory Agents.

ABSTRACT: Background/Objectives: Recently, the prevalence of diseases such as diabetes, arthritis, and inflammatory diseases, along with their complications, has become a significant health problem. This is in addition to the various biomedical applications of pyrazole, isatin, and indole derivatives. Accordingly, cooperation will continue between chemistry scientists, pharmaceutical scientists, and human doctors to produce hybrid compounds from pyrazole with isatin or indole possessing biological activities as anti-diabetic, anti-arthritic, and anti-inflammatory agents. Methods: The two series of pyrazole-isatin conjugates 12a-h and pyrazole-indole conjugates 14a-d were prepared from our previous works via the direct reaction of 5-amino-pyrazoles 10a

SUBMITTER: Naglah AM 

PROVIDER: S-EPMC11946580 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature