A Biopolymeric Dextran-Chitosan Delivery System for Controlled Release of Antioxidant and Anti-Inflammatory Compounds: Lignin and Curcumin.

ABSTRACT: Biopolymeric drug delivery systems enhance the bioavailability and therapeutic efficacy of poorly soluble bioactive compounds. In this study, chitosan (Chi), dextran (Dex), carboxymethyl dextran (mDex), lignin (L), and curcumin (Cu) were combined to develop materials with controlled release, antioxidant, and anti-inflammatory properties. The mechanical evaluation showed that Chi-mDex-L-Cu exhibited the highest diametral tensile strength (2.40 MPa), a 1233% increase compared to Chi-mDex-L, due to strong hydrogen bonding interactions between curcumin and matrix components. Curcumin release kinetics, modeled using the Weibull equation, demonstrated that Chi-mDex-L-Cu presented the slowest release rate, reducing the cumulative release by 55.66% as compared to Chi-L-Cu, ensuring prolonged bioac

SUBMITTER: Cucu P 

PROVIDER: S-EPMC11946708 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature