Evidence for Auditory Stimulus-Specific Adaptation But Not Deviance Detection in Larval Zebrafish Brains.

ABSTRACT: Animals receive a constant stream of sensory input, and detecting changes in this sensory landscape is critical to their survival. One signature of change detection in humans is the auditory mismatch negativity (MMN), a neural response to unexpected stimuli that deviate from a predictable sequence. This process requires the auditory system to adapt to specific repeated stimuli while remaining sensitive to novel input (stimulus-specific adaptation [SSA]). MMN was originally described in humans, and equivalent responses have been found in other mammals and birds, but it is not known to what extent this deviance detection circuitry is evolutionarily conserved. Here we present the first evidence for SSA in the brain of a teleost fish, using whole-brain calcium imaging of larval zebrafish at si

SUBMITTER: Wilde M 

PROVIDER: S-EPMC11946781 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature