A short-term, high-caloric diet has prolonged effects on brain insulin action in men.

ABSTRACT: Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.

SUBMITTER: Kullmann S 

PROVIDER: S-EPMC11946887 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature