Cell-autonomous innate immunity by proteasome-derived defence peptides.

ABSTRACT: For decades, antigen presentation on major histocompatibility complex class I for T cell-mediated immunity has been considered the primary function of proteasome-derived peptides^1,2. However, whether the products of proteasomal degradation play additional parts in mounting immune responses remains unknown. Antimicrobial peptides serve as a first line of defence against invading pathogens before the adaptive immune system responds. Although the protective function of antimicrobial peptides across numerous tissues is well established, the cellular mechanisms underlying their generation are not fully understood. Here we uncover a role for proteasomes in the constitutive and bacterial-induced generation of defence peptides that impede bacterial growth both in vitro and in vivo by di

SUBMITTER: Goldberg K 

PROVIDER: S-EPMC11946893 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature