Differential protection against SARS-CoV-2 reinfection pre- and post-Omicron.

ABSTRACT: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly evolved over short timescales, leading to the emergence of more transmissible variants such as Alpha and Delta^1-3. The arrival of the Omicron variant marked a major shift, introducing numerous extra mutations in the spike gene compared with earlier variants^1,2. These evolutionary changes have raised concerns regarding their potential impact on immune evasion, disease severity and the effectiveness of vaccines and treatments^1,3. In this epidemiological study, we identified two distinct patterns in the protective effect of natural infection against reinfection in the Omicron versus pre-Omicron eras. Before Omicron, natural infection provided strong and durable protection against rein

SUBMITTER: Chemaitelly H 

PROVIDER: S-EPMC11946897 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature