GABAergic neuron-to-glioma synapses in diffuse midline gliomas.

ABSTRACT: High-grade gliomas (HGGs) are the leading cause of brain cancer-related death. HGGs include clinically, anatomically and molecularly distinct subtypes that stratify into diffuse midline gliomas (DMGs), such as H3K27M-altered diffuse intrinsic pontine glioma, and hemispheric HGGs, such as IDH wild-type glioblastoma. Neuronal activity drives glioma progression through paracrine signalling^1,2 and neuron-to-glioma synapses^3-6. Glutamatergic AMPA receptor-dependent synapses between neurons and glioma cells have been demonstrated in paediatric³ and adult⁴ high-grade gliomas, and early work has suggested heterogeneous glioma GABAergic responses⁷. However, neuron-to-glioma synapses mediated by neurotransmitters other than glutamate remain unde

SUBMITTER: Barron T 

PROVIDER: S-EPMC11946904 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature