Plasmodium blood stage development requires the chromatin remodeller Snf2L.

ABSTRACT: The complex life cycle of the malaria parasite Plasmodium falciparum involves several major differentiation stages, each requiring strict control of gene expression. Fundamental changes in chromatin structure and epigenetic modifications during life cycle progression suggest a central role for these mechanisms in regulating the transcriptional program of malaria parasite development^1-6. P. falciparum chromatin is distinct from other eukaryotes, with an extraordinarily high AT content (>80%)⁷ and highly divergent histones resulting in atypical DNA packaging properties⁸. Moreover, the chromatin remodellers that are critical for shaping chromatin structure are not conserved and are unexplored in P. falciparum. Here we identify P. falciparum Snf2L (PfSnf2L, enc

SUBMITTER: Watzlowik MT 

PROVIDER: S-EPMC11946908 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature