Left-right-alternating theta sweeps in entorhinal-hippocampal maps of space.

ABSTRACT: Place cells in the hippocampus and grid cells in the entorhinal cortex are elements of a neural map of self position^1-5. For these cells to benefit navigation, their representation must be dynamically related to the surrounding locations². A candidate mechanism for linking places along an animal's path has been described for place cells, in which the sequence of spikes in each cycle of the hippocampal theta oscillation encodes a trajectory from the animal's current location towards upcoming locations^6-8. In mazes that bifurcate, such trajectories alternately traverse the two upcoming arms when the animal approaches the choice point^9,10, raising the possibility that the trajectories express available forward paths encoded on previous trials¹⁰

SUBMITTER: Vollan AZ 

PROVIDER: S-EPMC11946909 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature