PWP1 transcriptionally regulates p53, modulating apoptosis and cell cycle to promote gastric cancer progression.

ABSTRACT: Gastric cancer remains a leading cause of cancer-related mortality worldwide. The prognosis often depends on early detection and understanding the molecular mechanisms involved in its progression. Periodic tryptophan protein 1 (PWP1) has emerged as a novel diagnostic marker, potentially linked to gastric cancer progression. This study aims to elucidate the impact of PWP1 on gastric cancer development, focusing on apoptosis, cell cycle regulation, and the role of p53. This study utilized gastric cancer cell lines to investigate the expression and functional role of Pwp1. Quantitative PCR and Western blot analyses were conducted to measure PWP1 expression levels. Apoptosis was assessed by using flow cytometry and TUNEL assays, and cell cycle analysis was performed to evaluate the impact of P

SUBMITTER: Jiang M 

PROVIDER: S-EPMC11947051 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature